Phytochemicals Category : Alkaloid

PhytoCAT-ID Phytochemical name or plant extracts Source of phytochemicals or plant Extracts Target gene or protein Cell line/ mice model
PhytoCAT-25 Flavopereirine Geissospermum sericeum p-ERK, p38 MAPK siRNA, p-Akt, mTOR, LC3-II MCF-7, MDA-MB-231
PhytoCAT-31 Isotetrandrine Triclisia sacleuxii P-gp MCF-7/DOX, HeLa, Hep3B
PhytoCAT-32 Magnoflorine Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families Berberis cretica NA NCI-H1299, MDA-MB-468, T98G , TE671
PhytoCAT-40 5-hydroxy-skytanthine hydrochloride Tecoma stans NA Hep-G2, MCF-7
PhytoCAT-148 Klugine Psychotria klugii HIF-1 T47D
PhytoCAT-149 Isocephaeline Psychotria klugii HIF-1 T47D
PhytoCAT-150 Emetine Psychotria klugii HIF-1 T47D
PhytoCAT-173 Homoharringtonine Cephalotaxus harringtonia Bcl-x, Caspase 9 MCF-7, A549, UACC903
PhytoCAT-220 Chelidonine Chelidonium majus AKT, ERK1/2 MDA-MB-231
PhytoCAT-230 Papaverine Papaver rhoeas NA MCF-7, MDA-MB-231
PhytoCAT-243 Capsaicin Capsicum annuum NA MCF-7
PhytoCAT-244 Tomatine Solanum lycopersicum MMP2, MMP9, MMP9\NGAL MCF-7
PhytoCAT-266 Cyclovirobuxine D (CVB-D) Buxus microphylla LC3-I, LC3-II, ATG5 MCF-7
PhytoCAT-302 Terminamines K Pachysandra terminalis NA MDA-MB-231
PhytoCAT-303 Terminamines L Pachysandra terminalis NA MDA-MB-231
PhytoCAT-304 Terminamines M Pachysandra terminalis NA MDA-MB-231
PhytoCAT-305 Terminamines N Pachysandra terminalis NA MDA-MB-231
PhytoCAT-306 Terminamines O Pachysandra terminalis NA MDA-MB-231
PhytoCAT-307 Terminamines P Pachysandra terminalis NA MDA-MB-231
PhytoCAT-308 Terminamines Q Pachysandra terminalis NA MDA-MB-231
PhytoCAT-309 Terminamines R Pachysandra terminalis NA MDA-MB-231
PhytoCAT-310 Terminamines S Pachysandra terminalis NA MDA-MB-231
PhytoCAT-311 (+)-pachysandrine B Pachysandra terminalis NA MDA-MB-231
PhytoCAT-312 Epipachysandrine-A Pachysandra terminalis NA MDA-MB-231
PhytoCAT-313 3β-methylamino 16-oxo 5,17(20) cis-pregnadiene Pachysandra terminalis NA MDA-MB-231
PhytoCAT-314 Z-salignone Pachysandra terminalis NA MDA-MB-231
PhytoCAT-315 Terminamine H Pachysandra terminalis NA MDA-MB-231
PhytoCAT-316 3β-methylamino 16-oxo 5,17(20) trans-pregnadiene Pachysandra terminalis NA MDA-MB-231
PhytoCAT-317 E-salignone Pachysandra terminalis NA MDA-MB-231
PhytoCAT-318 (+)-spiropachysine Pachysandra terminalis NA MDA-MB-231
PhytoCAT-319 Terminamines A Pachysandra terminalis Epithelial growth factor, integrin β MDA-MB-231
PhytoCAT-320 Terminamines B Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-321 Terminamines C Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-322 Terminamines D Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-323 Terminamines E Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-324 Terminamines F Pachysandra terminalis NA MDA-MB-231
PhytoCAT-325 Terminamines G Pachysandra terminalis NA MDA-MB-231
PhytoCAT-326 Pachystermine B Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-327 Pachystermine A Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-328 Epipachysamine E Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-329 Epipachysamine B Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-330 Terminaline Pachysandra terminalis Epithelial growth factor MDA-MB-231
PhytoCAT-331 Terminamine I Pachysandra terminalis NA MDA-MB-231
PhytoCAT-332 Terminamine J Pachysandra terminalis NA MDA-MB-231
PhytoCAT-340 Avenanthramide-C Avena sativa NA MDA-MB-231
PhytoCAT-346 Neobractatin Garcinia bracteata MBNL2 MDA-MB-231 xenografts mouse model, A549, HepG2, T98, MCF-7
PhytoCAT-500 Benzo[b]tryptanthrin Indigofera tinctoria topo I, topo II, MDR1, Caspase 3, PARP HCT15, MCF-7
PhytoCAT-515 Matrine Sophora flavescens PTEN, miR-21 , AKT, Bad, p21(/WAF1/CIP1), p27(/KIP1), Bcl-2, Bax, VEGF, VEGFR-2, Caspase 3, Caspase 9, P-gp, MRP1, IKKβ, GRP78, eIF2α, CHOP, p62, mTOR, Topo I, LIN28A/Let-7 MCF-7, 4T1 Balb/c mice, MCF-7/ADR, MDA-MB-231, BT-474, MDA-MB-468
PhytoCAT-519 Tonkinensine B Sophora tonkinensis Bax, Bcl-2, Caspase 3, Caspase 9 MDA-MB-231, 4T1
PhytoCAT-543 5,6-anhydrohupehenine Fritillaria hupehensis NA MCF-7, HepG2
PhytoCAT-558 Colchicine Buddleja davidii NA Mgc-803, BCap-37, MDA-MB-435, MDA-MB-231, OVCAR3
PhytoCAT-586 Rohitukine Dysoxylum binectariferum NA MCF-7, T47D, MDA-MB-273, SKOV3, NCI/ADR-RES
PhytoCAT-601 Sinomenine Sinomenium acutum TRAP, OSCAR, c-Fos, NFATc1, hIL-8, IL-8/CXCR1, MMP2, MMP9 Tumor-bearing mice, MDA-MB-231
PhytoCAT-602 6,7-di-O-acetylsinococuline (FK-3000) Stephania delavayi NF-kB, COX-2, cyclin B, p-CDC2 MDA-MB-231 xenografted mice, MCF-7, MDA-MB-231, PC-3, HT-29
PhytoCAT-603 Sinococuline Stephania delavayi NA MDA-MB-231 xenografted mice, MCF-7, MDA-MB-231, PC-3, HT-29
PhytoCAT-605 Cepharanthine Stephania epigaea Atg7, AMPK MDA-MB-231, HeLa, A549, MCF-7, PC3, HepG2, Hep3B, 50MT-1, HL-60, H1299, SMMC-7721, SW480
PhytoCAT-606 Isotrilobine Stephania japonica NA MCF-7/ADR
PhytoCAT-607 Trilobine Stephania japonica NA MCF-7/ADR
PhytoCAT-639 Yuehchukene Murraya paniculata NA MCF-7, MDA-MB-231
PhytoCAT-659 Jerantinine A Tabernaemontana corymbosa SF3B1, SF3B3 MCF-7, MDA-MB-468, T47D, MCF-10A
PhytoCAT-665 Camptothecine Miquelia dentata NA MDA-MB-273, NCI/ADR-RES, SKOV, HepG2, Hep3B, MDA-MB- 231, MCF-7, A549, Ca9-22, NCI/ADR-RES, Hela, HCT116, GI 101A, MDA-MB-157
PhytoCAT-678 Lycorine Sternbergia clusiana Mcl-1, Bcl-xL, MMP2, MMP9, SHP-1, STAT-3 Nude mouse models, A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60
PhytoCAT-681 Govaniadine Corydalis govaniana Bax, p53, Survivin, Caspase 7 MCF-7
PhytoCAT-682 Corydalis saxicola Bunting total alkaloids (CSBTA) Corydalis saxicola RANKL/OPG MDA-MB-231
PhytoCAT-683 Glaucine Corydalis turtschaninovii MMP9, NF-κB MDA-MB-231
PhytoCAT-684 Leptopidine Hypecoum leptocarpum FAS NA
PhytoCAT-685 Noscapine Papaver somniferum Bcl-xL, Bcl-2 MCF-7 and MDA-MB-231
PhytoCAT-686 Sanguinarine Sanguinaria canadensis STAT-3 , XIAP, Caspase 3, Bcl-2, cIAP2, XIAP, c-FLIPs, p21, p27, Cyclin D1, Topoisomerase II NA
PhytoCAT-689 Piperlongumine Piper longum SETDB1, EGFR, STAT-3, ZBTB4, Sp1, Sp3, Sp4, Cyclin D1, Survivin, cMyc, EGFR A549, 786-O, SKBR-3, Female athymic nu/nu mice
PhytoCAT-721 Delcosine Aconitum barbatum Aconitum napellus Aconitum yesoense NA MCF-7, MDA-MB-231, A549, DU145,KB
PhytoCAT-722 Sinchiangensine A Aconitum sinchiangense NA HL-60, A-549, SMCC-7721, MCF-7 and SW480 cell line.
PhytoCAT-729 Protoberberine Coptis chinensis NA MCF-7, MADB106, SGC7901
PhytoCAT-730 Jatrorrhizine Coptis chinensis TNIK MDA-MB-231, MCF-7 and 4T1
PhytoCAT-737 Berberine Coptis chinensis EGFR, GPER1, ABCG2, CYP1A1, HMGB1, ABCG2, IL-1β, IL-6,TNF-α, NF-κB, Bax, Bcl-2, EGFR, AKT, P38, ERK1/2 Cytotoxic effect on MCF-7 cells, inhibitory effect on the growth of breast, liver and colon cancer cell lines (MCF-7, HepG2 and CACO-2, respectively). MDA-MB-231, the human ductal breast epithelial tumor cell line (T47D cell line)
PhytoCAT-761 3,10,11-trimethoxy-1,2-methylenedioxy-7-oxoaporphine Fissistigma oldhamii NA MCF-7
PhytoCAT-787 Mitraphylline Uncaria tomentosa NA HAE, BEAS-2B, SK-N-SH, HepG2, HEK293, MKN45, DLD1, A549, MCF7, LNCaP
PhytoCAT-789 8-hydroxyartabonatine C Pseuduvaria trimera NA HepG2, MDA-MB-231
PhytoCAT-799 Mukonal Murraya koenigii PARP, Caspase 3, Bcl-2, Beclin-1, LC3B-I, LC3B-II MDA-MB-231, CAMA-1, MDA-MB-435, SKBR-3/ xenografted mice models
PhytoCAT-811 Girinimbine Murraya euchrestifolia NA MDA-MB-453
PhytoCAT-812 Mahanine Bergera koenigii NA MDA‑MB‑157, MCF‑7, MDA-MB-231
PhytoCAT-814 Paratrimerin I Paramignya trimera NA MCF-7, HepG2
PhytoCAT-816 Harmine Peganum harmala Twist1, TAZ, p‑Erk, p‑Akt, Bcl‑2, Bax BT-549
PhytoCAT-817 Harmine hydrochloride Peganum harmala PI3K, AKT, mTOR, FOXO3a MCF-7, MDA-MB-231
PhytoCAT-820 Nitidine chloride Zanthoxylum nitidum PARP, Bax, Caspase 9, Caspase 3, Bcl-2 MCF-7, MDA-MB-231
PhytoCAT-826 Halofuginone Dichroa febrifuga MMP9 MDA-MB-231, PC3
PhytoCAT-847 Melognine Melodinus fusiformis Caspase 3, p53, Bcl-2 BT-549
PhytoCAT-855 9-methoxycanthin-6-one Eurycoma longifolia PKM, ANXA2, LGAL3, HNRNP1A1, PRDX3, GAPDH, ACAA2, ALDH1A1, CAPG,MDH2, EEF1A1, TPI1 MCF-7, A2780, SKOV-3, HT29, A375, HeLa, DU-145, RD, CaOV-3, MDBK, A-549
PhytoCAT-856 Canthin-6-one Eurycoma longifolia NA HCC 1395, DU 145, Vero E6, A549, MCF-7, HL60 , AZ521, SKBR-3
PhytoCAT-858 Picrasidine G Picrasma quassioides Caspase 3, PARP, STAT-3, EGFR, Survivin MDA-MB-468
PhytoCAT-862 Isopicrinine Rhazya stricta PUMA, Survivin MCF-7
PhytoCAT-863 Rhazyaminine Rhazya stricta Bcl-2 MCF-7
PhytoCAT-865 Affinisine Tabernaemontana catharinensis NA MCF-7, U251, NCI-ADR/RES, 786-0, NCI-H460, HT-29, K562 , PC-3
PhytoCAT-912 Boehmeriasin A Boehmeria siamensis Cyclin E2, Cyclin D1 MDA-MB-231
PhytoCAT-982 Dehydrocorydaline Corydali syanhusuo CDK1, CCND1, Bcl-2, MMP2, MMP9, Caspase 3, Caspase 8, Caspase 9, Bax, Bcl-2 MDA‑MB‑231 , MCF-7
PhytoCAT-983 Protopine Corydalis yanhusuo EGFR, ICAM-1, αv-integrin, β1-integrin, β5-integrin MCF-7, MDA-MB-231
PhytoCAT-1002 Evodiamine Evodia rutaecarpa MMP9, uPA, uPAR, ERK, p38 MAPK, topo I, Bax, Bcl-2, Caspase 3, Survivin MDA-MB-231, MCF-7, A375-S2, HeLa, THP-1, L929
PhytoCAT-1005 Tryptanthrin Cephalantheropsis gracilis NA  MCF-7, NCI-H460, and SF-268, HCT-15
PhytoCAT-1009 Voacamine Voacanga africana NA MDA-MB-231, HEPG-2, A375, SH-SY5Y, CT26
PhytoCAT-1010 19-epi-voacristine Voacanga africana NA MDA-MB-231, HEPG-2, A375, SH-SY5Y, CT26
PhytoCAT-1011 Vobasine  Voacanga africana NA MDA-MB-231, HEPG-2, A375, SH-SY5Y, CT26
PhytoCAT-1012 Voacristine  Voacanga africana NA MDA-MB-231, HEPG-2, A375, SH-SY5Y, CT26
PhytoCAT-1015 Voacangine  Voacanga africana NA MDA-MB-231, HEPG-2, A375, SH-SY5Y, CT27
PhytoCAT-1017 Curcumin and berberine combination Curcumin - Curcuma longa Berberine - Thalictrum delavayi Bcl-2, JNK, Beclin-1 MCF-7, MDA-MB-231
PhytoCAT-1080 Ukrain Chelidonium majus NA SKBR-3, 4T07, TUBO, MDA-MB-231, PA-TU-8902, CCL-221 , U-138MG
PhytoCAT-1089 Cuscutamine Cuscuta chinensis NA MCF-7, T47D
PhytoCAT-1137 Hirsutine Uncaria tomentosa γH2AX, Caspase 3, Caspase 7 MCF-7, MDA-MB-231, MDA-MB-468, MDA-MB-453, ZR-75-1, BT-474
PhytoCAT-1143 Isoliensinine Nelumbo nucifera p38 MAPK, JNK, CDK2, p21, AKT, GSK3α MCF-7, MDA-MB-231, HeLa, A549, PC3, HepG2, Hep3B, H1299
PhytoCAT-1144 Neferine (NEF) Nelumbo nucifera miR-374a/FGFR-2 MDA-MB-231, MCF-7
PhytoCAT-1189 Oxymatrine Sophora flavescens αⅤβ3 integrin, E-cadherin, FAK, PI3K, and Akt MCF-7, MDA-MB-231 and 4T1
PhytoCAT-1217 Clausehainanines A Clausena hainanensis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1218 Clausehainanines B Clausena hainanensis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1219 Clausehainanines C Clausena hainanensis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1220 Clausehainanines D Clausena hainanensis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1221 Clausehainanines E Clausena hainanensis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1262 Lucidimine B Ganoderma lucidum NA MCF-7
PhytoCAT-1307 Cordatine Macleaya cordata NA MCF-7 and SF-268
PhytoCAT-1308 8-methoxydihydrochelerythrine Macleaya cordata NA MCF-7, SF-269
PhytoCAT-1377 9-methoxy-18,19-dehydrocamptothecin Nothapodytes foetida NA HepG2, Hep3B, MDA-MB- 231, MCF-7, A549, and Ca9-22
PhytoCAT-1378 9-methoxy-camptothecin Nothapodytes foetida NA HepG2, Hep3B, MDA-MB- 231, MCF-7, A549, and Ca9-22
PhytoCAT-1379 5-hydroxycamptothecin Nothapodytes foetida NA HepG2, Hep3B, MDA-MB- 231, MCF-7, A549, and Ca9-22
PhytoCAT-1380 5-hydroxy-9-methoxycamptothecin Nothapodytes foetida NA HepG2, Hep3B, MDA-MB- 231, MCF-7, A549, and Ca9-22
PhytoCAT-1388 Conophylline Tabernaemontana divaricata, Tabernaemontana corymbosa NA HL-60, SMMC-7721, A-549, MCF-7, SW480, KB, PC-3, LNCaP, MDA-MB-231, HT-29, and HCT 116
PhytoCAT-1429 Nauclorienine Nauclea orientalis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1430 Antirhine Nauclea orientalis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1431 Iso-antirhine Nauclea orientalis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1432 Alangine Nauclea orientalis NA HL-60, SMMC-7721, A-549, MCF-7, SW480
PhytoCAT-1478 Kopsifoline I Kopsia fruticosa NA HS-1, HS-4, SCL-1, A431, BGC-823, MCF-7, and W480
PhytoCAT-1479 Kopsifoline J Kopsia fruticosa NA HS-1, HS-4, SCL-1, A431, BGC-823, MCF-7, and W480
PhytoCAT-1480 Kopsifoline K Kopsia fruticosa NA HS-1, HS-4, SCL-1, A431, BGC-823, MCF-7, and W480
PhytoCAT-1494 Ellipticine Berrywood tree, Asparagus cochinchinensis ALDH1A1, Bax, Bcl-2, XIAP, cyt-c, Caspase 3, Caspase 9, p53, KIP1/p27 MCF-7, MDA-MB-231/ HCT116 xenograft mouse tumor
PhytoCAT-1502 Piperine Piper nigrum Piper longum MMP2 and -9 mRNA, GLO1, SREBP-1, FAS, CXCL7, sICAM-1, L-selectin A549, MDA-MB-231, HepG2, MCF-7
PhytoCAT-1511 Stachydrine hydrochloride Leonurus cardiaca Caspase 3, Bcl-2, AKT, ERK MCF-7 , T47D
PhytoCAT-1547 Sarchookloide A Sarcococca hookeriana NA Hela, A549, MCF-7, SW480, and CEM
PhytoCAT-1548 Sarchookloide B Sarcococca hookeriana NA Hela, A549, MCF-7, SW480, and CEM
PhytoCAT-1549 Sarchookloide C Sarcococca hookeriana NA Hela, A549, MCF-7, SW480, and CEM
PhytoCAT-1556 Vincristine Catharanthus roseus Tp53, Bax, Bcl-2 mRNA , miR-222-3p BT-20, SKBR- 3, MCF-7
PhytoCAT-1557 Vinblastine Catharanthus roseus Tp53, Bax, Bcl-2 mRNA , miR-222-3p BT-20, SKBR- 3
PhytoCAT-1572 Cephalinone-F Cephalanceropsis gracilis NA MCF-7, NCI-H460, and SF-268
PhytoCAT-1738 Pterogynine (PGN) Pterogyne nitens NA ZR-7530
PhytoCAT-1739 Pterogynidine (PGD) Pterogyne nitens NA ZR-7530
PhytoCAT-1746 Taspine Radix et Rhizomaeonticis ER, PR ZR-75-30 human breast cancer xenografts in athymic mice
PhytoCAT-1764 Vinorelbine NA Caspase 3, Caspase 9, Caspase 8, cyt-c, Bid, HER2, Tp53, Bax, Bcl-2 mRNA , miR-222-3p MX-1, MCF-7
PhytoCAT-1841 Coptisine Coptidis rhizoma NA MDA-MB-231
PhytoCAT-1883 Boldine Lindera umbellata p38, ERK, JNK MCF-7, MDA-MB-231, Tumor-bearing mice
PhytoCAT-1898 Apomorphine NA NA MCF-7
PhytoCAT-1914 (+)-Tengerensine Ficus fistulosa NA MDA-MB-468, MDA-MB-231, and MCF-7
PhytoCAT-1915 Tengechlorenine Ficus fistulosa NA MDA-MB-468, MDA-MB-231, and MCF-7
PhytoCAT-1956 Tetrahydropalmatine (THP) and Berberine (Ber) Corydalis yanhusuo W. T. Wang NA MDA-MB-231
PhytoCAT-1995 (+)-baphicacanthcusines A Baphicacanthus cusia NA MCF-7
PhytoCAT-1996 (-)-baphicacanthcusines A Baphicacanthus cusia NA MCF-7
PhytoCAT-1997 (-)-baphicacanthcusines B Baphicacanthus cusia NA MCF-7
PhytoCAT-2005 Flavensomycinoic acid Culture filtrate of endophytic Streptomyces sp. YIM66017 from Alpinia oxyphylla NA MCF-7
PhytoCAT-2016 Berbamine Berberis amurensis SNAP29, VAMP8, BNIP3, VAMP8, Bcl-2, Bax, pro-MMP9/pro-MMP2, c-met , AKT, nuclear factor kappaB p-65, Bcl-2/Bax, osteopontin, VEGF, MMP9, MMP2 MDA-MB-231, MDA-MB-435S
PhytoCAT-2017 Tylophorine Tylophora indica Caspase 3, Caspase 9 T47D
PhytoCAT-2110 6, 7-dimethoxy-1-(α-hydroxy-4-methoxybenzyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline Annona squamosa NA HepG-2, MCF-7, HCT-116
PhytoCAT-2111 Coclaurine Annona squamosa NA HepG-2, MCF-7, HCT-116
PhytoCAT-2115 Luotonin A Peganum nigellastrum NA MCF-7, HeLa
PhytoCAT-2157 Lobeline Lobelia inflata P-gp Caco-2, CCRF-CEM, MDA-MB-231pcDNA3-BCRP-clone23
PhytoCAT-2159 Thaliblastine (TBL) Thalictrum foliolosum P-gp MCF/AdR