| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-681 | |
| Phytochemical name or plant extracts | Govaniadine | |
| PMID | 30140694 | |
| Literature evidence | In this study, cytotoxic activity and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall. roots were determined on human breast cancer (MCF-7) cells. | |
| IUPAC name | (13S)-16-methoxy-6,8-dioxa-1-azapentacyclo[11.8.0.03,11.05,9.014,19]henicosa-3,5(9),10,14(19),15,17-hexaen-15-ol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Corydalis govaniana | |
| Geographical availability | Afghanistan, Nepal, Pakistan, Tibet, West Himalaya | |
| Plant parts | whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, p53, Survivin, Caspase 7 | |
| Gene or Protein evidence | Govaniadine-induced apoptosis was also accompanied by upregulation of Bax, p53, and Survivin mRNA expression as assessed by real time PCR analysis. Caspase-7 was significantly activated in treated MCF-7 cells. | |
| Target pathways | NA | |
| IC50 | At 24h, 48h, 72 h: 3.05±0.27 μM against MCF-7 respectively 2.52±0.31 μM against MCF-7 respectively 1.6±0.23 μM against MCF-7 respectively | |
| Potency | The results indicate that govaniadine has potent and selective cytotoxic effects against MCF-7 cells and the potential to induce caspase 7 dependent apoptosis in MCF-7 cells by activation of pathways that lead to oxidative stress. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Govaniadine-treated MCF-7 cells also showed enhanced levels of intracellular reactive oxygen species (ROS) and glutathione S-transferase (GST) and decreased levels of glutathione (GSH). | |
| PubChem ID | 102144689 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:672252-1 | |
| Safety | NA |