| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-983 | |
| Phytochemical name or plant extracts | Protopine | |
| PMID | 25435628 | |
| Literature evidence | CONCLUSION: The present results suggest that protopine seems to inhibit the heterotypic cell adhesion between MDA-MB-231 cells, and human umbilical vein endothelial cells by changing the expression of adhesive factors. | |
| IUPAC name | 15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Corydalis yanhusuo | |
| Geographical availability | China South-Central, China Southeast | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | EGFR, ICAM-1, αv-integrin, β1-integrin, β5-integrin | |
| Gene or Protein evidence | The results showed that after treatment with protopine for 90 min, the expression of EGFR, ICAM-1, αv-integrin, β1-integrin and β5-integrin were remarkably reduced. | |
| Target pathways | NA | |
| IC50 | 29.45 μM against MCF-7 | |
| Potency | The present results suggest that protopine seems to inhibit the heterotypic cell adhesion between MDA-MB-231 cells, and human umbilical vein endothelial cells by changing the expression of adhesive factors. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | In five tested alkaloids, only protopine exhibited anti-adhesive and anti-invasion effects in MDA-MB-231 cells, which contributed to the anti-metastasis effect of Corydalis yanhusuo. | |
| PubChem ID | 4970 | |
| Additional PMIDs | 23860409 24317429 26626193 26084170 29567254 33530428 23358674 25435628 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:929107-1 | |
| Safety | NA |