| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1548 | |
| Phytochemical name or plant extracts | Sarchookloide B | |
| PMID | 29762510 | |
| Literature evidence | All three amide substituted steroidal alkaloids exhibited significant cytotoxic activities with IC50 values of 1.05�31.83 μM. | |
| IUPAC name | (3E)-1-[(1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-[(1S)-1-(dimethylamino)ethyl]-8-hydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-3-methylpent-3-en-2-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Sarcococca hookeriana | |
| Geographical availability | China North-Central, China South-Central, East Himalaya, Nepal, Tibet | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer, Colon cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 28.53 ± 0.17 µM against MCF-7 | |
| Potency | CEM in vitro. All three amide substituted steroidal alkaloids exhibited significant cytotoxic activities with IC50 values of 1.05?31.83 µM. | |
| Cell line/ mice model | Hela, A549, MCF-7, SW480, and CEM | |
| Additional information | Furthermore, all active compounds showed effects that were comparable to the chemotherapeutic drug adriamycin in inhibiting the growth of all cancer cells, which suggests that three amide-substituted pregnane-type steroidal alkaloids might have the potential to be anticancer agents. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:355988-1 | |
| Safety | NA |