| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1262 | |
| Phytochemical name or plant extracts | Lucidimine B | |
| PMID | 30023870 | |
| Literature evidence | The former alkaloid arrested the MCF-7 cell cycle in the S phase by inducing DNA fragmentation, hence reducing the mitochondrial membrane potential. | |
| IUPAC name | 8-oxa-17-azatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2(7),3,5,10,15-hexaen-4-ol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Ganoderma lucidum | |
| Geographical availability | NA | |
| Plant parts | Spores or Fruiting body | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Loss of MMP is considered as a pathway for apoptosis, and increase of MMP loss could lead to the activation of apoptosis-inducing factors from mitochondria, which promotes apoptosis by inactivating inhibitors of apoptosis proteins. | |
| IC50 | NA | |
| Potency | lucidimine B exhibited antiproliferative properties toward MCF-7 cells (an EC50 value of 0.27 ± 0.02 μmol/mL). | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Lucidimine B could induce DNA fragmentation and impact cell cycle progression at the S phase. | |
| PubChem ID | 139583498 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://www.iihr.res.in/reishi-mushroom-ganoderma-lucidum | |
| Safety | NA |