| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-789 | |
| Phytochemical name or plant extracts | 8-hydroxyartabonatine C | |
| PMID | 24968332 | |
| Literature evidence | Compounds 1 and 2 exhibited cytotoxic activity with IC50 values of 26.36±5.18 μM and 12.88±2.49 μM, respectively, for human hepatocellular carcinoma HepG2 cells, and 64.75±4.45 and 67.06±3.5 μM, respectively, for human breast cancer MDA-MB231 cells. | |
| IUPAC name | 6-hydroxy-11,12,16-trimethoxy-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2(7),3,5,9,11,13,15-octaen-8-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Pseuduvaria trimera | |
| Geographical availability | China South-Central, Myanmar, Thailand, Vietnam | |
| Plant parts | Leaves and twigs | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 64.75±4.45 μM against MDA-MB-231 | |
| Potency | Compound 1 and 2 displayed anti-cancer activity and have potential for use as anti-cancer drugs in human liver and breast cancer. | |
| Cell line/ mice model | HepG2, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77076786-1 | |
| Safety | NA |