| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-730 | |
| Phytochemical name or plant extracts | Jatrorrhizine | |
| PMID | 31302315 | |
| Literature evidence | CONCLUSION: These findings provide an overall perspective that jatrorrhizine potentially restrains TNIK regulating Wnt/β-catenin signalling and EMT expression for mammary cancer targeted therapy. | |
| IUPAC name | 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Coptis chinensis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | TNIK | |
| Gene or Protein evidence | The results showed that targeted knockout of TNIK that attenuated Wnt/β-catenin signalling and epithelial-mesenchymal transition (EMT) expression, the effects were potentiated by the addition of jatrorrhizine. | |
| Target pathways | TNIK regulating Wnt/β-catenin signalling and EMT expression | |
| IC50 | 11.08 ± 1.19 μM against MDA-MB-231 17.11 ± 4.54 μM against MCF-7 22.14 ± 2.87 μM against 4T1 | |
| Potency | These findings provide an overall perspective that jatrorrhizine potentially restrains TNIK regulating Wnt/β-catenin signalling and EMT expression for mammary cancer targeted therapy. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 and 4T1 | |
| Additional information | Here, we found that JAT could ameliorate NLRP3-N-GSDMD-dependent pyroptosis induced by MNV infection through inhibiting the MAPKs/NF-κB signaling pathways and decrease MNV replication in RAW264.7 macrophages, suggesting that JAT has the potential to be a therapeutic agent for treating norovirus gastroenteritis. | |
| PubChem ID | 72323 | |
| Additional PMIDs | 30963783 36680009 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:710313-1 | |
| Safety | These results were further corroborated by the 4T1 tumour-bearing mice, which showed that jatrorrhizine significantly suppressed the proliferation and metastasis of mammary carcinoma cells without obvious toxicity. |