| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1005 | |
| Phytochemical name or plant extracts | Tryptanthrin | |
| PMID | 25686035 | |
| Literature evidence | Among the compounds isolated, tryptanthrin (6), phaitanthrin A (7), cephalinone D (19), and flavanthrin (30) showed significant cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines. | |
| IUPAC name | indolo[2,1-b]quinazoline-6,12-dione | |
| Phytochemicals’ class or type of plant extracts | Indoloquinazoline alkaloid | |
| Source of phytochemicals or plant Extracts | Cephalantheropsis gracilis | |
| Geographical availability | Assam, Bangladesh, China South-Central, China Southeast, Hainan, Japan, Laos, Maluku, Myanmar, Nansei-shoto, Philippines, Taiwan, Thailand, Vietnam | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Lung cancer, Glioma | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 9.4 ± 0.3 μM against MCF-7 | |
| Potency | Taken together, derivatization by benzo-annulation of tryptanthrin ameliorated the MDR-reversing effect of tryptanthrin and may pave the way to the discovery of a novel potent adjuvant agent for chemotherapy. © 2015 WILEY-VCH Verlag GmbH & Co. | |
| Cell line/ mice model | MCF-7, NCI-H460, and SF-268, HCT-15 | |
| Additional information | Inhibits both topoisomerases I (topo I) and II (topo II) Benzo[b]tryptanthrin - a derivative of tryptanthrin- inhibits both topo I and topo II, causes cleavage of caspase-3 and PARP in HCT15 colon cancer cells, reverses adriamycin resistance by down-regulation of multidrug resistance protein 1 (MDR1) in adriamycin-resistant MCF7 breast cancer cells (MCF7adr) | |
| PubChem ID | 73549 | |
| Additional PMIDs | 25809558 18507473 32501005 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:622415-1 | |
| Safety | NA |