| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-820 | |
| Phytochemical name or plant extracts | Nitidine chloride | |
| PMID | 25027404 | |
| Literature evidence | Nitidine chloride (NC) is a natural bioactive alkaloid that has recently been reported to have diverse anticancer properties. | |
| IUPAC name | 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium,chloride | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Zanthoxylum nitidum | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, Laos, Malaya, Maluku, Myanmar, Nansei-shoto, Nepal, New Guinea, Philippines, Queensland, Sulawesi, Taiwan, Thailand, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP, Bax, Caspase 9, Caspase 3, Bcl-2 | |
| Gene or Protein evidence | Using western blot analysis, we found that NC upregulated the pro-apoptotic proteins Bax, cleaved caspase-9 and -3 and cleaved PARP and that it downregulated the anti-apoptotic proteins Bcl-2 and PARP. | |
| Target pathways | c-Src/FAK associated signaling pathway | |
| IC50 | 7.47 μM against MCF-7 at 24 h 6.79 μM against MDA-MB-231 at 24 h | |
| Potency | Our study demonstrated the anticancer effect of NC on breast cancer and highlighted the potential clinical application of NC. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | In addition, NC exhibited a synergistic effect with doxorubicin on the growth inhibition of the human breast cancer cell lines MCF-7 and MDA-MB-231. | |
| PubChem ID | 25659 | |
| Additional PMIDs | 25027404 21959111 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:775896-1 | |
| Safety | NA |