| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-683 | |
| Phytochemical name or plant extracts | Glaucine | |
| PMID | 25670016 | |
| Literature evidence | Taken together, our findings indicate that the MMP-9 inhibitory activity of glaucine and its abilities to attenuate IκBα and NF-κB activities may be therapeutically useful as a novel means of controlling breast cancer growth and invasiveness. | |
| IUPAC name | (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Corydalis turtschaninovii | |
| Geographical availability | Amur, China North-Central, Chita, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye | |
| Plant parts | Tuber | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP9, NF-κB | |
| Gene or Protein evidence | Results from reporter gene and electrophoretic mobility shift assays revealed that glaucine inhibits MMP-9 expression by suppressing activation of the nuclear transcription factor nuclear factor-κB (NF-κB). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Finally, we also found that glaucine inhibits invasion and MMP-9 expression in the highly metastatic MDA-MB-231 breast cancer cell line. Taken together, our findings indicate that the MMP-9 inhibitory activity of glaucine and its abilities to attenuate IκBα and NF-κB activities may be therapeutically useful as a novel means of controlling breast cancer growth and invasiveness. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Glaucine depressed the contractile responses to Ca2+ (pD'2 approximately 3.62) and reduced the sustained rise of [Ca2+]i produced by histamine in cultured human airway smooth muscle cells (-log IC50 approximately 4.3). | |
| PubChem ID | 16754 | |
| Additional PMIDs | 24317429 25670016 10455321 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:672558-1 | |
| Safety | NA |