| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2017 | |
| Phytochemical name or plant extracts | Tylophorine | |
| PMID | 30485942 | |
| Literature evidence | Background: The effects of tylophorine, a natural alkaloid found in Tylophora indica, administered as a single compound or in combination with doxorubicin on cell cycling and apoptosis were assessed in T47D breast cancer cells, selected as a model system for breast cancer. | |
| IUPAC name | (13aS)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizine | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Tylophora indica | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, India, Laccadive Is., Laos, Malaya, Myanmar, Nicobar Is., Sri Lanka, Sumatera, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 9 | |
| Gene or Protein evidence | Expression of proapoptotic proteins (caspases 3 and 9) was up-regulated upon administration of tyloporine alone or in combination with doxorubicin. | |
| Target pathways | NA | |
| IC50 | 113 μM against T47D | |
| Potency | Tylophorine alone or in combination with doxorubicin induced apoptosis in T47D breast cancer cells through modulation of the cell cycle and affecting the expression of caspases 3 and 9. | |
| Cell line/ mice model | T47D | |
| Additional information | NA | |
| PubChem ID | 92114 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:102486-1 | |
| Safety | NA |