| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1388 | |
| Phytochemical name or plant extracts | Conophylline | |
| PMID | 23944995 | |
| Literature evidence | All compounds except for 3 were evaluated for their cytotoxicity against five human cancer cell lines, conophylline showed significant bioactivity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC₅₀ values of 0.17, 0.35, 0.21, 1.02, and 1.49 μM, respectively. | |
| IUPAC name | dimethyl 14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo[23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40]tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Tabernaemontana divaricata, Tabernaemontana corymbosa | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, India, Laos, Myanmar, Nepal, Thailand, Vietnam, West Himalaya Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, Hainan, Laos, Lesser Sunda Is., Malaya, Myanmar, Sumatera, Thailand, Vietnam | |
| Plant parts | Aerial parts Leaves | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer, Colon cancer, Leukemia, Squamous cell cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1.02 µM against MCF-7 5.4 ± 0.4 µM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7, SW480, KB, PC-3, LNCaP, MDA-MB-231, HT-29, and HCT 116 | |
| Additional information | NA | |
| PubChem ID | 9853848 | |
| Additional PMIDs | 30869890 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:82097-1 , https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60466167-2 | |
| Safety | NA |