| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-639 | |
| Phytochemical name or plant extracts | Yuehchukene | |
| PMID | 10601799 | |
| Literature evidence | Yuehchukene (YCK) is a novel bis-indole alkaloid with weak estrogenic activity. Biochemical studies showed that YCK could attenuate estrogenic action. | |
| IUPAC name | (6S,6aS,10aR)-6-(1H-indol-3-yl)-7,7,9-trimethyl-6,6a,8,10a-tetrahydro-5H-indeno[2,1-b]indole | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Murraya paniculata | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, Christmas I., East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal , New Guinea, New South Wales, Northern Territory, Philippines, Queensland, Solomon Is., Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vanuatu, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Roots | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | On the other hand, a low concentration ( approximately 10(-8)-10(-9) M) of YCK was found to potentiate the cytotoxic effect of cyclophosphamide on the MCF-7 cell line. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | These findings, together with the dual role of a mixed estrogen and anti-estrogen effect, suggested that YCK and cyclophosphamide can be a potential combination in chemo-hormonal therapy for breast cancer. | |
| PubChem ID | 126009 | |
| Additional PMIDs | 7828637 10601799 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:774441-1 | |
| Safety | NA |