| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-812 | |
| Phytochemical name or plant extracts | Mahanine | |
| PMID | 31251988 | |
| Literature evidence | Mahanine (MH), a Alkaloid isolated from an edible plant (Murraya koenigii), potentially inhibits the growth of altered subtypes of breast cancer cells in vitro and significantly reduced the mammary tumor burden in N-Methyl-N-nitrosourea (MNU) induced rat. | |
| IUPAC name | (3R)-3,5-dimethyl-3-(4-methylpent-3-enyl)-11H-pyrano[3,2-a]carbazol-9-ol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Bergera koenigii | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Laos, Malaya, Nepal, Pakistan, Sri Lanka, Thailand, Vietnam, West Himalaya | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The experimental results showed that 20-25 μM of MH for 24 h of treatment was very potent to reduce the cell proliferation through apoptosis with arresting the cells in G0/G1 in both ER+/p53WT MCF-7 and triple negative/p53Mut MDA-MB-231 cells. | |
| Cell line/ mice model | MDA‑MB‑157, MCF‑7, MDA-MB-231 | |
| Additional information | Further, in vivo observation indicated that intraperitoneal injection of MH for four weeks with a dose of 50 mg/kg body weight thrice in a week, significantly (P = 0.03) reduced the mammary tumor weight in MNU induced rat. In conclusion, this study provides the novel insight into the mechanism of MH mediated growth arrest in subtype irrespective breast cancer progression. | |
| PubChem ID | 36689305 | |
| Additional PMIDs | 27982755 22105714 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:774433-1 | |
| Safety | NA |