| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1557 | |
| Phytochemical name or plant extracts | Vinblastine | |
| PMID | 15752896 | |
| Literature evidence | In this study, we assessed the potential interactions in the combination of vincristine or vinblastine with gamma-radiation against human tumor cells in vitro. | |
| IUPAC name | methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Catharanthus roseus | |
| Geographical availability | Madagascar | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer, Multiple myeloma, Lymphoma | |
| Target gene or protein | Tp53, Bax, Bcl-2 mRNA , miR-222-3p | |
| Gene or Protein evidence | Treatment of BT-20 cells with vincristine, vinblastine, and/or vinorelbine resulted in upregulation of TP53 expression. On the other hand, treatment of SK-BR-3 cells with any of these vinca alkaloids led to an increase in the BAX/BCL2 mRNA ratio, implying the activation of the intrinsic apoptotic pathway. No concomitant alteration in TP53 expression was observed in treated SKBR- 3 cells. Regarding the miRNAs examined in this study, miR-222-3p expression exhibited the most remarkable modulations in both treated cell lines. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | BT-20, SKBR- 3 | |
| Additional information | Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca++ -transport ATPase activity, cellular respiration, and nucleic acid and lipid biosynthesis. This study suggests the possible involvement of miR-222-3p expression in breast cancer cell apoptosis, triggered by vincristine, vinblastine, and vinorelbine. | |
| PubChem ID | 13342 | |
| Additional PMIDs | 16555127 7407762 22924480 30166916 30261584 30901766 34062037 23145786 25298669 30416351 21342795 23273047 26774597 28006904 28250653 1446601 18566577 11801563 15337839 17154505 17069615 12425469 19001156 8708838 28860494 31759031 25738318 27542708 7656116 15026547 15752896 19626437 19184019 22122393 3880657 3011256 6422004 4005794 6469498 28787019 3689368 2671933 2057177 1283849 1524896 8727715 7913408 8882953 8877249 16230404 1972771 6861260 19288491 30417784 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77880-1 | |
| Safety | NA |