| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-863 | |
| Phytochemical name or plant extracts | Rhazyaminine | |
| PMID | 30373413 | |
| Literature evidence | OBJECTIVE: Identify and characterize new compounds from RS, which inhibit gene(s) involved in the survival, invasion, self-renewal, and metastatic processes of cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Rhazya stricta | |
| Geographical availability | Afghanistan, Gulf States, India, Iran, Iraq, Oman, Pakistan, Saudi Arabia, West Himalaya, Yemen | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2 | |
| Gene or Protein evidence | Rhazyaminine from Rhazya stricta Inhibits Metastasis and Induces Apoptosis by Downregulating Bcl-2 Gene in MCF7 Cell Line | |
| Target pathways | Wnt/β-catenin pathway. | |
| IC50 | NA | |
| Potency | R.A successfully downregulated key genes involved in apoptosis, cell survival, epithelial-mesenchymal transition, cancer stem cell proliferation, and Wnt signal transduction pathway making it an excellent "lead candidate" molecule for in vivo proof-of-concept studies. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | We observed that R.A treatment downregulated two genes, LGR4 and CAMK2B, which are key players in the Wnt/β-catenin pathway. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:81712-1 | |
| Safety | NA |