| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-787 | |
| Phytochemical name or plant extracts | Mitraphylline | |
| PMID | 19724995 | |
| Literature evidence | This action suggests that the pentacyclic oxindole alkaloid mitraphylline might be a new promising agent in the treatment of both human sarcoma and breast cancer. | |
| IUPAC name | methyl (1S,4aS,5aS,6R,10aR)-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Uncaria tomentosa | |
| Geographical availability | Belize, Bolivia, Brazil North, Colombia, Costa Rica, Ecuador, French Guiana, Guatemala, Guyana, Honduras, Nicaragua, Panamá, Peru, Suriname, Trinidad-Tobago, Venezuela | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, human aortic endothelial cancer, bronchial cancer, neuronal cancer, hepatic cancer, kidney cancer, gastric cancer, colon cancer, lung cancer, prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | The IC (50) +/- SE values were 17.15 +/- 0.82 μM for MHH-ES-1 and 11.80 +/- 1.03 μM for MT-3 for 30 hours, smaller than those obtained for the reference compounds. | |
| Potency | Micromolar concentrations of mitraphylline (5 microM to 40 microM) inhibited the growth of both cell lines in a dose-dependent manner. | |
| Cell line/ mice model | HAE, BEAS-2B, SK-N-SH, HepG2, HEK293, MKN45, DLD1, A549, MCF7, LNCaP | |
| Additional information | This action suggests that the pentacyclic oxindole alkaloid mitraphylline might be a new promising agent in the treatment of both human sarcoma and breast cancer. | |
| PubChem ID | 94160 | |
| Additional PMIDs | 19724995 28966251 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:768322-1 | |
| Safety | NA |