| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-586 | |
| Phytochemical name or plant extracts | Rohitukine | |
| PMID | 19686817 | |
| Literature evidence | Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. | |
| IUPAC name | 5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-2-methylchromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Dysoxylum binectariferum | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, Hainan, India, Laos, Myanmar, Nepal, Nicobar Is., Sri Lanka, Thailand, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Ovarian cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 50 µg/uL against T47D 3 µg/uL against MDA-MB-273 15 µg/uL against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, T47D, MDA-MB-273, SKOV3, NCI/ADR-RES | |
| Additional information | Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested. | |
| PubChem ID | 13422573 | |
| Additional PMIDs | 21898150 19686817 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:578076-1 | |
| Safety | NA |