| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-346 | |
| Phytochemical name or plant extracts | Neobractatin | |
| PMID | 31320607 | |
| Literature evidence | We found that Neobractatin (NBT), a natural compound isolated from Garcinia bracteata, could efficiently inhibit breast and lung cancer cells metastasis. | |
| IUPAC name | (12R,13S)-7-hydroxy-5-methoxy-15,15-dimethyl-4-(2-methylbut-3-en-2-yl)-13-(3-methylbut-2-enyl)-2,14-dioxapentacyclo[11.4.1.01,10.03,8.012,16]octadeca-3(8),4,6,10-tetraene-9,18-dione | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Garcinia bracteata | |
| Geographical availability | Assam, Bangladesh, China South-Central, China Southeast, East Himalaya, Myanmar, Thailand | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | MBNL2 | |
| Gene or Protein evidence | Based on the RNA-sequencing result and transcriptome analysis, Muscleblind-like 2 (MBNL2) was found to be significantly upregulated in the cells treated with NBT. | |
| Target pathways | pAKT/EMT signaling pathway | |
| IC50 | 2.82 ± 0.43 μM against MDA-MB-231 6.27 ± 1.03 μM against MCF-7 | |
| Potency | This study suggest that NBT possesses significant antitumor activity in breast and lung cancer cells that is partly mediated through the MBNL2 expression and enhancement in metastasis via the pAKT/EMT signaling pathway. | |
| Cell line/ mice model | MDA-MB-231 xenografts mouse model, A549, HepG2, T98, MCF-7 | |
| Additional information | Subsequent in vivo study showed the same metastasis inhibition effect in NBT and MBNL2 in MDA-MB-231 xenografts mouse model. | |
| PubChem ID | 101508194 | |
| Additional PMIDs | 33142411 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:427802-1 | |
| Safety | NA |