| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-150 | |
| Phytochemical name or plant extracts | Emetine | |
| PMID | 15974627 | |
| Literature evidence | Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells. | |
| IUPAC name | (2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Psychotria klugii | |
| Geographical availability | Colombia, Ecuador, Peru | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | HIF-1 | |
| Gene or Protein evidence | Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells | |
| Target pathways | NA | |
| IC50 | 0.11 μM against T47D | |
| Potency | NA | |
| Cell line/ mice model | T47D | |
| Additional information | NA | |
| PubChem ID | 10219 | |
| Additional PMIDs | 12880315 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:212953-2 | |
| Safety | NA |