| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-603 | |
| Phytochemical name or plant extracts | Sinococuline | |
| PMID | 25823424 | |
| Literature evidence | These studies demonstrate that FK-3000, isolated from S. delavayi Diels., is a promising, pathway-specific anticancer agent that exhibits low toxicity. | |
| IUPAC name | (1S,9S,12S,13S)-4,11-dimethoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraene-3,12,13-triol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Stephania delavayi | |
| Geographical availability | China South-Central, Myanmar | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 4.49 μg/ml against MDA-MB-231 14.45 μg/ml against MCF-7 | |
| Potency | Sinococuline was less effective than S. delavayi Diels. extract at inhibiting growth in the six cancer lines tested. | |
| Cell line/ mice model | MDA-MB-231 xenografted mice, MCF-7, MDA-MB-231, PC-3, HT-29 | |
| Additional information | Sinococuline inhibits secretion of viral antigen NS1 and prevents pan-DENV infection | |
| PubChem ID | 5489400 | |
| Additional PMIDs | 36658277 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:581412-1 | |
| Safety | NA |