| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1883 | |
| Phytochemical name or plant extracts | Boldine | |
| PMID | 27611982 | |
| Literature evidence | Exposure to boldine decreased bromodeoxyuridine incorporation and histone H3 phosphorylation but did not induce apoptosis. | |
| IUPAC name | (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Lindera umbellata | |
| Geographical availability | Japan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p38, ERK, JNK | |
| Gene or Protein evidence | Boldine treatment resulted in p38, ERK, and JNK activation in the mitogen-activated protein kinase pathway in a dose-dependent manner. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Boldine was cytotoxic to MCF-7 cells and reduced their viability and proliferation in vitro. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, Tumor-bearing mice | |
| Additional information | There was neither antagonism nor synergism between boldine and doxorubicin, except a possible synergism of i. p. boldine 90 mg/kg combined with doxorubicin when compared with doxorubicin alone.Boldine was cytotoxic to MCF-7 cells and reduced their viability and proliferation in vitro. Exposure to boldine decreased bromodeoxyuridine incorporation and histone H3 phosphorylation but did not induce apoptosis. | |
| PubChem ID | 10154 | |
| Additional PMIDs | 25746354 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:465469-1 | |
| Safety | NA |