| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-31 | |
| Phytochemical name or plant extracts | Isotetrandrine | |
| PMID | 18717331 | |
| Literature evidence | The ability of isotetrandrine to inhibit P-gp function was reversible, because incubation of MCF-7/DOX cells with isotetrandrine caused a marked increase in uptake and a notable decrease in efflux of Rh123 and a marked increase of intracellular DOX concentrations. | |
| IUPAC name | (1S,14R)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene | |
| Phytochemicals’ class or type of plant extracts | Isoquinoline alkaloid | |
| Source of phytochemicals or plant Extracts | Triclisia sacleuxii | |
| Geographical availability | Angola, Central African Repu, Congo, Gabon, Kenya, Mozambique, Tanzania | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Liver cancer, | |
| Target gene or protein | P-gp | |
| Gene or Protein evidence | The ability of isotetrandrine to inhibit P-gp function was reversible, because incubation of MCF-7/DOX cells with isotetrandrine caused a marked increase in uptake and a notable decrease in efflux of Rh123 and a marked increase of intracellular DOX concentrations. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7/DOX, HeLa, Hep3B | |
| Additional information | In conclusion, isotetrandrine exhibited potent effect on the reversal of P-gp-mediated MDR in vitro, suggesting that it might become a candidate of effective MDR reversing agent in cancer chemotherapy. Prominent antiproliferative compounds include: isoquinoline alkaloid isotetrandrine | |
| PubChem ID | 457825 | |
| Additional PMIDs | 28626426 18717331 27373319 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:581679-1 | |
| Safety | NA |