| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-244 | |
| Phytochemical name or plant extracts | Tomatine | |
| PMID | 25466288 | |
| Literature evidence | Upon emergence of modern anticancer therapy, medical community is divided into two opposite camps, one of them claiming absolute necessity of using isolated or synthesized chemical compounds for efficient patient treatment and another one advocating alternative cancer therapies, in particular those based on natural sources, including extracts from plants. | |
| IUPAC name | (2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(1R,2S,4S,5'S,6S,7S,8R,9S,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-piperidine]-16-yl]oxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Solanum lycopersicum | |
| Geographical availability | Peru | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP2, MMP9, MMP9\NGAL | |
| Gene or Protein evidence | Activation of MMP-2, MMP-9 and MMP-9\NGAL has been shown to decrease significantly in cells treated with tomatine by gelatin zymography compared to the control. | |
| Target pathways | NA | |
| IC50 | 7.07 μM against MCF-7 | |
| Potency | As a result, matrix metalloproteinase activity and cell proliferation were suppressed by tomatine and this may provide support in treatment methods. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 28523 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316947-2 | |
| Safety | NA |