| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-659 | |
| Phytochemical name or plant extracts | Jerantinine A | |
| PMID | 28198434 | |
| Literature evidence | Jerantinine A (JA) is a novel indole alkaloid which displays potent anti-proliferative activities against human cancer cell lines by inhibiting tubulin polymerization and inducing G2/M cell cycle arrest. | |
| IUPAC name | methyl (1R,12R,19S)-12-ethyl-4-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,9,13-pentaene-10-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Tabernaemontana corymbosa | |
| Geographical availability | Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, Hainan, Laos, Lesser Sunda Is., Malaya, Myanmar, Sumatera, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | SF3B1, SF3B3 | |
| Gene or Protein evidence | Using a combined pooled-genome wide shRNA library screen and global proteomic profiling, we showed that JA targets the spliceosome by up-regulating SF3B1 and SF3B3 protein in breast cancer cells. | |
| Target pathways | NA | |
| IC50 | 0.72 ± 0.18 μM against T47D 0.86 ± 0.09 μM against MDA-MB-468 1.22 ± 0.15 μM against MCF-7 | |
| Potency | Jerantinine A (JA) is a novel indole alkaloid which displays potent anti-proliferative activities against human cancer cell lines by inhibiting tubulin polymerization and inducing G2/M cell cycle arrest. | |
| Cell line/ mice model | MCF-7, MDA-MB-468, T47D, MCF-10A | |
| Additional information | Further analyses showed that JA stabilizes endogenous SF3B1 protein in breast cancer cells and induced dissociation of the protein from the nucleosome complex. Together, these results demonstrate that JA exerts its antitumor activity by targeting SF3B1 and SF3B3 in addition to its reported targeting of tubulin polymerization. | |
| PubChem ID | 25112179 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60466167-2 | |
| Safety | NA |