| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-847 | |
| Phytochemical name or plant extracts | Melognine | |
| PMID | 31674840 | |
| Literature evidence | Further mechanism of action study indicated that melognine demonstrated the ability to induce apoptosis by activation of caspase-3 and p53, and downregulation of Bcl-2 in BT549 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Monoterpenoid alkaloid | |
| Source of phytochemicals or plant Extracts | Melodinus fusiformis | |
| Geographical availability | Cambodia, China South-Central, China Southeast, Laos, Philippines, Thailand, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, p53, Bcl-2 | |
| Gene or Protein evidence | Further mechanism of action study indicated that melognine demonstrated the ability to induce apoptosis by activation of caspase-3 and p53, and downregulation of Bcl-2 in BT549 cells. | |
| Target pathways | NA | |
| IC50 | 1.49 μM against BT-549 | |
| Potency | NA | |
| Cell line/ mice model | BT-549 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:80201-1 | |
| Safety | NA |