| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1009 | |
| Phytochemical name or plant extracts | Voacamine | |
| PMID | 26140390 | |
| Literature evidence | Among them, compounds 2 and 6 displayed significant inhibitory activities, compounds 3, 4 and 5 showed moderate inhibitory activities, while compounds 1 and 7 showed no inhibitory activities against the five cell lines. | |
| IUPAC name | methyl (1S,15S,17S,18S)-17-ethyl-6-[(1R,12R,14R,15E)-15-ethylidene-18-methoxycarbonyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraen-12-yl]-7-methoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Monoterpenoid alkaloid | |
| Source of phytochemicals or plant Extracts | Voacanga africana | |
| Geographical availability | Angola, Benin, Burkina, Burundi, Cabinda, Cameroon, Central African Repu, Congo, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Gulf of Guinea Is., Ivory Coast, Kenya, Liberia, Malawi, Mali, Mozambique, Nigeria, Senegal, Sierra Leone, Sudan, Tanzania, Togo, Uganda, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Liver cancer, Skin cancer, Neuroblastoma | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 5.5 +/- 1.4 μg/mL against MDA-MB-231 | |
| Potency | Among them, compounds 2 and 6 displayed significant inhibitory activities, compounds 3, 4 and 5 showed moderate inhibitory activities, while compounds 1 and 7 showed no inhibitory activities against the five cell lines. Compound 2 is Voacamine | |
| Cell line/ mice model | MDA-MB-231, HEPG-2, A375, SH-SY5Y, CT26 | |
| Additional information | Voacamine and its combination with Tamoxifen activated prolyl hydroxylase-2 to combat mammary gland carcinoma. | |
| PubChem ID | 11953931 | |
| Additional PMIDs | 34090331 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:82719-1 | |
| Safety | NA |