| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1080 | |
| Phytochemical name or plant extracts | Ukrain | |
| PMID | 23302993 | |
| Literature evidence | Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induce protective antitumor immunity in mice. | |
| IUPAC name | (1S,12S,13R)-24-[2-[bis[2-[(1S,12S,13R)-12-hydroxy-24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-24-yl]ethylamino]phosphinothioylamino]ethyl]-24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol,trihydroxide | |
| Phytochemicals’ class or type of plant extracts | Alkaloid thiophosphoric acid | |
| Source of phytochemicals or plant Extracts | Chelidonium majus | |
| Geographical availability | Albania, Algeria, Altay, Amur, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Canary Is., Central European Rus, China North-Central, China South-Central, China Southeast, Chita, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Greece, Hungary, Iran, Irkutsk, Italy, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Krym, Madeira, Manchuria, Mongolia, Morocco, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Portugal, Primorye, Qinghai, Romania, Sardegna, South European Russi, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Turkey-in-Europe, Tuva, Ukraine, West Siberia, Yakutskiya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Pancreatic cancer, Colorectal cancer, Glioma | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our findings demonstrate the in vitro and in vivo cytotoxic effects of Ukrain on breast cancer cells and may provide insight into designing Ukrain-based therapies for breast cancer patients. | |
| Cell line/ mice model | SKBR-3, 4T07, TUBO, MDA-MB-231, PA-TU-8902, CCL-221 , U-138MG | |
| Additional information | The anti-cancer drug Ukrain, a plant-derived semi-synthetic compound, has been shown to be effective in a variety of tumor models including colon, brain, ovarian, melanoma and lymphoma. | |
| PubChem ID | 160027 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:303589-2 | |
| Safety | NA |