| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-811 | |
| Phytochemical name or plant extracts | Girinimbine | |
| PMID | 34472799 | |
| Literature evidence | Girinimbine can inhibit both cancer cell migration as well as invasion. | |
| IUPAC name | 3,3,5-trimethyl-11H-pyrano[3,2-a]carbazole | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Murraya euchrestifolia | |
| Geographical availability | China South-Central, China Southeast, Hainan, Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | MEK/ERK/STAT3 pathway | |
| IC50 | NA | |
| Potency | In conclusion, it may be proposed that girinimbine could be a promising anticancer agent against breast cancer, provided further in-depth studies are carried out. | |
| Cell line/ mice model | MDA-MB-453 | |
| Additional information | Girinimbine has induced potent chromatin condensation and nuclear fragmentation. The percentage of both early and late apoptotic cells increased significantly after girinimbine exposure. | |
| PubChem ID | 96943 | |
| Additional PMIDs | 33316408 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:774423-1 | |
| Safety | NA |