| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2115 | |
| Phytochemical name or plant extracts | Luotonin A | |
| PMID | 28039786 | |
| Literature evidence | Luotonin A (L), a novel natural cytotoxic and anti-inflammatory alkaloid, chelated with copper(II) to improve its cytotoxic effect against the cancer cells. | |
| IUPAC name | 3,11,21-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,13,15,17,19-nonaen-10-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Peganum nigellastrum | |
| Geographical availability | Buryatiya, China North-Central, China Southeast, Inner Mongolia, Mongolia, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 7.0±0.15 μM against MCF-7 | |
| Potency | The IC50 values of L, complexes 1&2 against MCF-7 and HeLa cell lines with the incubation time intervals of 24hrs are 1 (5.0±0.25, 12.0±0.30μM)<2 (6.5±0.27, 15.0±0.30μM)<L (7.0±0.15, 25.0±0.35μM) respectively. | |
| Cell line/ mice model | MCF-7, HeLa | |
| Additional information | NA | |
| PubChem ID | 10334120 | |
| Additional PMIDs | 31815127 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:774547-1 | |
| Safety | NA |