| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-678 | |
| Phytochemical name or plant extracts | Lycorine | |
| PMID | 24566315 | |
| Literature evidence | Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. | |
| IUPAC name | (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Sternbergia clusiana | |
| Geographical availability | East Aegean Is., Iran, Iraq, Lebanon-Syria, Palestine, Turkey | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Mcl-1, Bcl-xL, MMP2, MMP9, SHP-1, STAT-3 | |
| Gene or Protein evidence | Lycorine also downregulated the expressions of STAT3 target genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, which are involved in apoptosis and invasion of breast cancer. Mechanistically, Lycorine significantly inhibited STAT3 phosphorylation and transcriptional activity through upregulating SHP-1 expression. | |
| Target pathways | Src/FAK-involved pathway STAT3 signaling pathway | |
| IC50 | NA | |
| Potency | Taken together, these findings suggest that Lycorine may be a promising candidate for the prevention and treatment of human breast cancer. | |
| Cell line/ mice model | Nude mouse models, A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60 | |
| Additional information | Results showed that Lycorine significantly suppressed cell proliferation, colony formation, migration and invasion, as well as induced cell apoptosis, but showed no apparent impact on cell cycle. | |
| PubChem ID | 72378 | |
| Additional PMIDs | 24566315 28910973 28251459 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:66887-1 | |
| Safety | NA |