| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-243 | |
| Phytochemical name or plant extracts | Capsaicin | |
| PMID | 25382686 | |
| Literature evidence | The abilities of capsaicin and capsaicin epoxide to induce oxidative stress were estimated using redox-sensitive fluorogenic probes: 2',7'-dichlorodihydrofluorescein diacetate (H2DCF-DA) and dihydroethidium. | |
| IUPAC name | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Capsicum annuum | |
| Geographical availability | Arizona, Bahamas, Belize, Bolivia, Brazil North, Brazil Northeast, Cayman Is., Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Florida, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Louisiana, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Peru, Puerto Rico, Southwest Caribbean, Suriname, Texas, Trinidad-Tobago, Turks-Caicos Is., Venezuela, Windward Is. | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our data indicate that the antiproliferative activity of capsaicin epoxide is potentiated in vitro, when used at much lower concentrations compared with capsaicin at similar concentrations. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Human breast carcinoma cells were found to be the most sensitive to capsaicin epoxide treatment compared with capsaicin treatment, and the action of capsaicin epoxide was oxidant based. | |
| PubChem ID | 1548943 | |
| Additional PMIDs | 14608115 34836251 33469265 34344261 31089409 31600949 32429317 34311277 26734584 34356536 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316944-2 | |
| Safety | NA |