| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1502 | |
| Phytochemical name or plant extracts | Piperine | |
| PMID | 26093789 | |
| Literature evidence | Piperine as a pungent alkaloid has been identified as the most potent adjuvant at enhancing the efficacy of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapies in triple-negative breast cancer (TNBC) cells in vitro and in vivo, which might be mediated through inhibition of Survivin. | |
| IUPAC name | (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Piper nigrum Piper longum | |
| Geographical availability | Piper nigrum - India Piper longum L. - Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, Laos, Myanmar, Nicobar Is., Thailand, Vietnam | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer | |
| Target gene or protein | MMP2 and -9 mRNA, GLO1, SREBP-1, FAS, CXCL7, sICAM-1, L-selectin | |
| Gene or Protein evidence | The in vitro migration of piperine-treated TNBC cells was impaired and expression of matrix metalloproteinase-2 and -9 mRNA was decreased, suggesting an antimetastatic effect by piperine. R-C-P results in cytotoxic effects in MCF-7 cells and that this outcome is associated with decreasing GLO1 activity and mitochondrial dysfunction. Blockade of ERK1/2 signaling by piperine significantly reduced SREBP-1 and FAS expression. Low piperine fractional P. nigrum extract suppressed some cytokine and chemokine levels including CXCL7, sICAM-1, and L-selectin 0.2- to 0.6-fold. | |
| Target pathways | Piperine also inhibited survival-promoting Akt activation in TNBC cells and caused caspase-dependent apoptosis via the mitochondrial pathway. | |
| IC50 | 238 µM against MDA-MB-231 | |
| Potency | Taken together, these findings suggest that piperine may be useful in the treatment of TNBC. | |
| Cell line/ mice model | A549, MDA-MB-231, HepG2, MCF-7 | |
| Additional information | Curcumin and piperine have been demonstrated to target breast cancer stem cells. These results suggest that piperine can reverse MDR by multiple mechanisms and it may be a promising lead compound for future studies. Collectively, these results suggested that piperine inhibited osteoclast differentiation by suppressing the p38/NFATc1/c-Fos signaling axis. | |
| PubChem ID | 638024 | |
| Additional PMIDs | 32014909 31963155 33902130 32276474 34559416 32721999 23870999 26627060 25444919 26093789 21802927 27178634 27155135 21295962 31767565 34482273 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:682369-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:682031-1 | |
| Safety | Show acute toxicity, as given in pubchem |