Phytochemical Name
Gene Name
Plant Name
Alphabetically
Entity List

FAQs

  1. What is PhytoCAT?
  2. How can I search for phytochemicals of interest?
  3. Can I search for biological activities and molecular target information of phytochemicals?
  4. Can I download the desired phytochemical’s structure?
  5. Can I get the information related to study type and safety for entities in the database?
  6. Can I get the geographical availability of source plant and plant parts from where the phytochemicals have been extracted?
  7. Can I get all research articles of particular phytochemicals in context with breast cancer?
  1. PhytoCAT is a curated repository of Phytochemicals for Cancer Affordable Therapeutics that exhibit activity against breast cancer. It contains 2147 entries including, phytochemicals, essential oils, plant extracts against breast cancer and each phytochemical provides information on its source, structure, properties (physical, elemental, and topological), cancer type, cell lines, inhibitory values (IC50), molecular targets, their geographical availability, and target pathways. PhytoCAT concentrates on anti-cancer natural compounds found in plants only with a particular focus on breast cancer. PhytoCAT is unique in providing bioactivities of these natural compounds against different cancer cell lines, mice model, molecular targets, and signaling pathways. Geographical availability and parts of the source plant from which phytochemical is extracted make it more beneficial to be taken for further studies. It includes data extracted from PubMed by text mining of 29020 abstracts. Each record in the PhytoCAT is also hyperlinked to various other similar databases like PubChem, Plants of the World Online (POWO), and PubMed.
  2. The desired chemical can be found in two different ways. Make use of the Search by Phytochemical name option if you are already familiar with the compound name. Otherwise, alphabetical search is available for the intended compound.
  3. The IC50 value of phytochemicals is provided in The IC50 value section, whereas the ED50, GI50 values are provided in the potency category. The information of molecular target is provided along with their evidence in the detailed information of each entity.
  4. The structure of phytochemicals can be downloaded from the PubChem by using hyperlink of PubChem ID provided in the PhytoCAT database.
  5. The in-vitro, in-vivo or in-silico studies of phytochemicals or plant extracts are provided in study type section of the database. In the safety section LC50 value is provided along with comparison of cancer cell with normal cells.
  6. The geographical accessibility of plants is crucial for drug discovery, biodiversity exploration, traditional medicine insights, bioprospecting, and quality monitoring of phytochemical extracts for therapeutic applications. This information is provided in the geographical availability section and detailed information about the plant parts used for extraction.
  7. The database includes numerous studies on phytochemicals' potential against breast cancer, with the most comprehensive information from multiple studies hyperlinked in additional PMIDs.