| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-855 | |
| Phytochemical name or plant extracts | 9-methoxycanthin-6-one | |
| PMID | 14575431 | |
| Literature evidence | These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines. | |
| IUPAC name | 13-methoxy-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Eurycoma longifolia | |
| Geographical availability | Borneo, Cambodia, Laos, Malaya, Myanmar, Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Roots | |
| Other cancers | Breast cancer, Ovarian cancer, Colorectal cancer, Skin cancer, Cervical Cancer, Prostate Cancer, Myosarcoma, Lung Cancer | |
| Target gene or protein | PKM, ANXA2, LGAL3, HNRNP1A1, PRDX3, GAPDH, ACAA2, ALDH1A1, CAPG,MDH2, EEF1A1, TPI1 | |
| Gene or Protein evidence | 9-methoxycanthine-6-one were found to affect the expressions of apoptotic-related proteins, that were proteins pyruvate kinase (PKM), annexin A2 (ANXA2), galectin 3 (LGAL3), heterogeneous nuclear ribonucleoprotein A1 (HNRNP1A1), peroxiredoxin 3 (PRDX3), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the differential analysis of 2-DE profiles between treated and non-treated 9-methoxycanthine-6-one. Proteins such as acetyl-CoA acyltransferase 2 (ACAA2), aldehyde dehydrogenase 1 (ALDH1A1), capping protein (CAPG), eukaryotic translation elongation factor 1 (EEF1A1), malate dehydrogenase 2 (MDH2), purine nucleoside phosphorylase (PNP), and triosephosphate isomerase 1 (TPI1) were also identified to be associated with A2780 cell death induced by 9-methoxycanthine-6-one. | |
| Target pathways | NA | |
| IC50 | 15.09 ± 0.99 µM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, A2780, SKOV-3, HT29, A375, HeLa, DU-145, RD, CaOV-3, MDBK, A-549 | |
| Additional information | Affects the expressions of apoptotic-related proteins, that were proteins pyruvate kinase (PKM), annexin A2 (ANXA2), galectin 3 (LGAL3), heterogeneous nuclear ribonucleoprotein A1 (HNRNP1A1), peroxiredoxin 3 (PRDX3), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), thus inducing apoptosis | |
| PubChem ID | 9881423 | |
| Additional PMIDs | 16317660 14575431 35163852 30974893 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:813715-1 | |
| Safety | NA |