| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-500 | |
| Phytochemical name or plant extracts | Benzo[b]tryptanthrin | |
| PMID | 25809558 | |
| Literature evidence | Taken together, derivatization by benzo-annulation of tryptanthrin ameliorated the MDR-reversing effect of tryptanthrin and may pave the way to the discovery of a novel potent adjuvant agent for chemotherapy. © 2015 WILEY-VCH Verlag GmbH & Co. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Indigofera tinctoria | |
| Geographical availability | Angola, Assam, Bangladesh, Botswana, Burkina, East Himalaya, Ghana, India, Laccadive Is., Malawi, Maldives, Mexico Gulf, Mexico Northeast, Mexico Southeast, Mexico Southwest, Mozambique, Myanmar, Nicobar Is., Northern Provinces, Pakistan, Peru, Senegal, Sri Lanka, Swaziland, Tanzania, Thailand, Vietnam, West Himalaya, Yemen, Zambia, Zimbabwe | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | topo I, topo II, MDR1, Caspase 3, PARP | |
| Gene or Protein evidence | Tryptanthrin and its benzo-annulated derivative, benzo[b]tryptanthrin, inhibit both topoisomerases I (topo I) and II (topo II) and cause cytotoxicity in several human cancer cell lines. Benzo[b]tryptanthrin induced apoptosis through the cleavage of caspase-3 and PARP in HCT15 colon cancer cells. Additionally, benzo[b]tryptanthrin reversed adriamycin resistance by down-regulation of multidrug resistance protein 1 (MDR1) in adriamycin-resistant MCF7 breast cancer cells (MCF7adr) with more potent inhibitory activity than tryptanthrin. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken together, derivatization by benzo-annulation of tryptanthrin ameliorated the MDR-reversing effect of tryptanthrin and may pave the way to the discovery of a novel potent adjuvant agent for chemotherapy. | |
| Cell line/ mice model | HCT15, MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:500111-1 | |
| Safety | NA |