| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1189 | |
| Phytochemical name or plant extracts | Oxymatrine | |
| PMID | 31496729 | |
| Literature evidence | Oxymatrine significantly inhibited cell migration and invasion, downregulated the expression of N-cadherin, vimentin, and Snail in MDA-MB-231 and 4T1 cells, but upregulated the expression of E-cadherin in 4T1 cells. | |
| IUPAC name | (1R,2R,9S,17S)-13-oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Sophora flavescens | |
| Geographical availability | Altay, Amur, China North-Central, China South-Central, China Southeast, Chita, Hainan, Inner Mongolia, Irkutsk, Japan, Khabarovsk, Korea, Manchuria, Mongolia, Primorye, Qinghai, Taiwan, Tibet, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | αⅤβ3 integrin, E-cadherin, FAK, PI3K, and Akt | |
| Gene or Protein evidence | Oxymatrine significantly inhibited cell migration and invasion, downregulated the expression of N-cadherin, vimentin, and Snail in MDA-MB-231 and 4T1 cells, but upregulated the expression of E-cadherin in 4T1 cells. The mechanism revealed that oxymatrine decreased the expression of αⅤ and β3 integrin and their co-localization. It also inhibited αⅤβ3 integrin downstream activation by suppressing the phosphorylation of FAK, PI3K, and Akt. | |
| Target pathways | Our results revealed that oxymatrine effectively reversed EMT in breast cancer cells by depressing αⅤβ3 integrin/FAK/PI3K/Akt signaling. | |
| IC50 | At 24 h: 34.55±1.48 μmol/mL against MDA-MB-231 At 48h: 23.71±0.31 μmol/mL against MDA-MB-231 At 72h : 12.45±1.98 μmol/mL against MDA-MB-231 | |
| Potency | Thus, oxymatrine could be a potential therapeutic candidate with anti-metastatic potential for the treatment of breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 and 4T1 | |
| Additional information | Our results demonstrated that oxymatrine effectively suppressed the viability of MDA-MB-231 and 4T1 breast cancer cells, and oxymatrine showed less cytotoxicity on normal breast mammary epithelial MCF-10A cells. Oxymatrine also caused a significant increase in the proportion of cells undergoing apoptosis in Hep G2 cells, albeit at a lower level than CKI | |
| PubChem ID | 114850 | |
| Additional PMIDs | 21069479 31496729 31578346 16012772 32161498 30678652 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:518831-1 | |
| Safety | NA |