| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1556 | |
| Phytochemical name or plant extracts | Vincristine | |
| PMID | 15752896 | |
| Literature evidence | In this study, we assessed the potential interactions in the combination of vincristine or vinblastine with gamma-radiation against human tumor cells in vitro. | |
| IUPAC name | methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Catharanthus roseus | |
| Geographical availability | Madagascar | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer, Multiple myeloma, Lymphoma | |
| Target gene or protein | Tp53, Bax, Bcl-2 mRNA , miR-222-3p | |
| Gene or Protein evidence | Treatment of BT-20 cells with vincristine, vinblastine, and/or vinorelbine resulted in upregulation of TP53 expression. On the other hand, treatment of SK-BR-3 cells with any of these vinca alkaloids led to an increase in the BAX/BCL2 mRNA ratio, implying the activation of the intrinsic apoptotic pathway. No concomitant alteration in TP53 expression was observed in treated SKBR- 3 cells. Regarding the miRNAs examined in this study, miR-222-3p expression exhibited the most remarkable modulations in both treated cell lines. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In addition, concomitant treatment of the MCF-7 cells with SKE and vincristine produced a potent anti-proliferative and pro-apoptotic effect compared to extract or drug alone. | |
| Cell line/ mice model | BT-20, SKBR- 3, MCF-7 | |
| Additional information | Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca++ -transport ATPase activity, cellular respiration, and nucleic acid and lipid biosynthesis. This study suggests the possible involvement of miR-222-3p expression in breast cancer cell apoptosis, triggered by vincristine, vinblastine, and vinorelbine. | |
| PubChem ID | 5978 | |
| Additional PMIDs | 24812569 29755565 15752896 19277662 3880657 18591064 19724995 23905023 26341291 30901766 32478999 7914453 34770804 12579872 12697374 6366133 7043753 6891324 7903202 7226124 18566577 15601545 23051672 18560226 26002042 12798338 7656116 19626437 19184019 22122393 3011256 3902268 3689368 30787205 2057177 7882462 9623323 7318120 35097257 1972771 6861260 15205350 30417784 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77880-1 | |
| Safety | NA |