| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-862 | |
| Phytochemical name or plant extracts | Isopicrinine | |
| PMID | 32463309 | |
| Literature evidence | Objective: The present study was designed to isolate a novel anticancer compound from Rhazya stricta and elucidate its mechanism of action using genomics approach. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Rhazya stricta | |
| Geographical availability | Afghanistan, Gulf States, India, Iran, Iraq, Oman, Pakistan, Saudi Arabia, West Himalaya, Yemen | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | PUMA, Survivin | |
| Gene or Protein evidence | One of the crucial proapoptotic genes, significantly upregulated in MCF7 after exposure to alkaloid, was PUMA (p53 upregulated modulator of apoptosis), which is involved in p53-dependent and -independent apoptosis. Moreover, exposure of sublethal dose of isopicrinine alkaloid in breast cancer cell line led to the downregulation of survivin, which is involved in negative regulation of apoptosis. | |
| Target pathways | p53 signaling pathway | |
| IC50 | 240 µM against MCF-7 | |
| Potency | In this article, we report the determination of a new alkaloid isopicrinine from the aerial parts of Rhazya stricta with anticancer property. This compound has the potential to be developed as a drug for curing cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | In vitro studies revealed that newly identified isopicrinine alkaloid possess efficient anticancer activity. Exposure of MCF7 cells with isopicrinine affected the expression of various genes involved in p53 signaling pathway. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:81712-1 | |
| Safety | NA |