| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-912 | |
| Phytochemical name or plant extracts | Boehmeriasin A | |
| PMID | 16445628 | |
| Literature evidence | In vitro biological activity assay demonstrated that this novel compound has wide-range, strong antitumor activity. | |
| IUPAC name | (14aS)-3,6,7-trimethoxy-11,12,13,14,14a,15-hexahydro-9H-phenanthro[9,10-b]quinolizine | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Boehmeria siamensis | |
| Geographical availability | China South-Central, China Southeast, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin E2, Cyclin D1 | |
| Gene or Protein evidence | Consistent with G1 arrest and cell growth inhibition, cyclin E2 and cyclin D1 messenger RNA expression in the cell was down-regulated with drug treatment. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The concentrations resulting in total and 50% growth inhibition are 0.007 and 0.0035 microg/mL, respectively. Exposed in 0.007 microg/mL boehmeriasin A for 12 h, the G1 phase cell percent increased from 44.8% pre-drug treatment to 66.3%. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The result first demonstrates that boehmeriasin A potently inhibits the proliferation of breast cancer cell MDA-MB-231 via the G1 phase cell cycle arrest and differentiation induction, and as such, may be considered as candidate chemotherapeutic and/or chemopreventive agent for breast cancer. | |
| PubChem ID | 52939850 | |
| Additional PMIDs | 14598211 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:850754-1 | |
| Safety | NA |