| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-607 | |
| Phytochemical name or plant extracts | Trilobine | |
| PMID | 9392886 | |
| Literature evidence | An alkaloidal extract of the vines of Stephania japonica showed multidrug-resistance-reversing activity as demonstrated by the bicinchoninic acid assay. | |
| IUPAC name | (8S,21S)-13,27-dimethoxy-7-methyl-15,29,31-trioxa-7,22-diazaoctacyclo[19.9.3.216,19.14,30.110,14.03,8.025,33.028,32]heptatriaconta-1(30),2,4(34),10(37),11,13,16,18,25,27,32,35-dodecaene | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Stephania japonica | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Japan, Jawa, Korea, Laos, Lesser Sunda Is., Malaya, Maluku, Marquesas, Myanmar, Nansei-shoto, Nepal, New Caledonia, New Guinea, New South Wales, Nicobar Is., Norfolk Is., Northern Territory, Philippines, Queensland, Samoa, Society Is., Solomon Is., Sri Lanka, Sulawesi, Sumatera, Thailand, Tonga, Vanuatu, Vietnam | |
| Plant parts | Vines | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The compounds were not significantly toxic to resistant cells (MCF-7/ADR) in the absence of doxorubicin (ED50: 2 µg/mL for isotrilobine and 1 µg/mL for trilobine) | |
| Cell line/ mice model | MCF-7/ADR | |
| Additional information | NA | |
| PubChem ID | 169007 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:581449-1 | |
| Safety | NA |