| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-25 | |
| Phytochemical name or plant extracts | Flavopereirine | |
| PMID | 31518562 | |
| Literature evidence | For breast cancer subtypes lacking targeted therapies, it is vitally essential to find novel agents that prevent chemoresistance and metastatic relapse. | |
| IUPAC name | 3-ethyl-12H-indolo[2,3-a]quinolizin-5-ium | |
| Phytochemicals’ class or type of plant extracts | β-carboline alkaloid | |
| Source of phytochemicals or plant Extracts | Geissospermum sericeum | |
| Geographical availability | Bolivia, Brazil North, Brazil Northeast, French Guiana, Guyana, Suriname, Venezuela | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | p-ERK, p38 MAPK siRNA, p-Akt, mTOR, LC3-II | |
| Gene or Protein evidence | Furthermore, we found that flavopereirine-induced apoptosis was partially reduced in MDA-MB-231 cells treated with an extracellular regulated kinase (ERK) inhibitor and p38 mitogen-activated protein kinase (MAPK) siRNA. Moreover, p38 siRNA treatment simultaneously reduced phosphorylated ERK expression levels. Conversely, the recovered phosphorylation of AKT decreased the levels of p-ERK and p-p38 MAPK. Western blotting showed that flavopereirine directly suppressed p-AKT levels and mammalian target of rapamycin (mTOR) translation. We found that flavopereirine induced microtubule-associated protein 1 light chain 3 (LC3)-II accumulation in a dose- and time-dependent manner in MDA-MB-231 cells. | |
| Target pathways | AKT/p38 MAPK/ERK signaling pathway | |
| IC50 | 5.96 μM against MDA-MB-231 12.43 μM against MCF-7 at 48 h | |
| Potency | We found that flavopereirine caused G0/G1 phase arrest in MCF-7 cells and S phase arrest in MDA-MB-231 cells. MDA-MB-231 cells were more sensitive to flavopereirine-induced apoptosis. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Overall, flavopereirine induces cell cycle arrest and the AKT/p38 MAPK/ERK signaling pathway, which contribute to flavopereirine-induced apoptosis in MDA-MB-231 cells. Flavopereirine has anti-proliferation ability in cancer cells, but whether it regulates autophagy in breast cancer cells remains unclear. | |
| PubChem ID | 65171 | |
| Additional PMIDs | 7075859 32731544 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1006780-1 | |
| Safety | NA |