| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-865 | |
| Phytochemical name or plant extracts | Affinisine | |
| PMID | 35075954 | |
| Literature evidence | The alkaloid affinisine (3) was the most promising, showing moderate inhibition rates in addition to the cytotoxic and cytocidal effect against all strains tested. | |
| IUPAC name | [(1S,12S,14R,15E)-15-ethylidene-3-methyl-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraen-13-yl]methanol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Tabernaemontana catharinensis | |
| Geographical availability | Argentina Northeast, Bolivia, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Paraguay, Uruguay | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Glioma, Ovarian cancer, Kidney cancer, Lung cancer, Colon cancer, Leukemia, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The alkaloid affinisine (3) was the most promising, showing moderate inhibition rates in addition to the cytotoxic and cytocidal effect against all strains tested. | |
| Cell line/ mice model | MCF-7, U251, NCI-ADR/RES, 786-0, NCI-H460, HT-29, K562 , PC-3 | |
| Additional information | It also proved to be a very promising compound, showing high selectivity rates when compared to the non-tumor keratinocyte cell line (HaCat). | |
| PubChem ID | 6325075 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:82043-1 | |
| Safety | NA |