| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-302 | |
| Phytochemical name or plant extracts | Terminamines K | |
| PMID | 27681716 | |
| Literature evidence | In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). | |
| IUPAC name | [(1R,3S,4R,5R,8S,9R,10R,11R,13S,14S,16S,17S)-4-acetyloxy-11-[(2S)-2-amino-2-methylbutanoyl]-17-[(1S)-1-(dimethylamino)ethyl]-16-hydroxy-10,13-dimethyl-3-[(3S)-2-oxo-3-propan-2-ylazetidin-1-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Pachysandra terminalis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Japan, Sakhalin | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.58 ± 0.06 μM against MDA-MB-231 | |
| Potency | Alkaloids 1, 5, 7, 9, 12, and 17 presented significant anti-metastasis activities compared with the positive reagent, LY294002. Compound 1 is Terminamines K | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 132508266 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:353208-1 | |
| Safety | NA |