| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-605 | |
| Phytochemical name or plant extracts | Cepharanthine | |
| PMID | 9219836 | |
| Literature evidence | The plasma trans-membrane potential was lower in 50MT-1 cells than in FM3A cells, although there were no differences in expressions of P-glycoprotein and of DNA topoisomerase-I and -II proteins. | |
| IUPAC name | (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Stephania epigaea | |
| Geographical availability | China South-Central | |
| Plant parts | Tuber | |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer, Liver cancer, Leukemia | |
| Target gene or protein | Atg7, AMPK | |
| Gene or Protein evidence | Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). | |
| Target pathways | AMPK-mTOR signaling | |
| IC50 | 9.45±1.13µM against MCF-7 5.61±1.51 µM against MDA-MB-231 | |
| Potency | Overall, the present study demonstrated that CEP had greater cell toxicity in 3D spheroids of breast cancer cells compared with TET, suggesting that CEP may have a stronger antitumor activity on TNBC spheroids compared with TET. | |
| Cell line/ mice model | MDA-MB-231, HeLa, A549, MCF-7, PC3, HepG2, Hep3B, 50MT-1, HL-60, H1299, SMMC-7721, SW480 | |
| Additional information | We conclude that the modification of plasma trans-membrane potential by cepharanthine should be effective in overcoming CPT-11 and multidrug resistance in 50MT-1 cells. Cepharanthine has been reported to be an efficient, less toxicmodulator for DOX-induced cytotoxicity. | |
| PubChem ID | 10206 | |
| Additional PMIDs | 23621840 28359054 33101499 9219836 26811496 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:581420-1 | |
| Safety | NA |