| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-558 | |
| Phytochemical name or plant extracts | Colchicine | |
| PMID | 22938042 | |
| Literature evidence | Subsequent fluorescence staining and flow cytometry analysis indicated that these two compounds could induce apoptosis in Mgc-803 cells. | |
| IUPAC name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Buddleja davidii | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Tibet | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Stomach cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 76.01±0.6 μM against Bcap-37 95 nM against MDA-MB-231 | |
| Potency | Colchicine and luteolin from B. davidii have potential applications as adjuvant therapies for treating human carcinoma cells. These compounds could also induce apoptosis in tumor cells. | |
| Cell line/ mice model | Mgc-803, BCap-37, MDA-MB-435, MDA-MB-231, OVCAR3 | |
| Additional information | Both of colchicines and luteolin showed potent anticancer activities on Bcap-37 and BGC-823 cells in a dose-dependent manner. | |
| PubChem ID | 6167 | |
| Additional PMIDs | 24983126 29673459 30230828 32750611 32919128 32805425 34858165 31724435 34309466 33465696 32981901 31927336 22705644 27262599 28757065 28211616 28079286 30197030 31653441 30845369 22938042 31788435 2023698 34206673 26246833 24876872 31366123 10217732 29793751 19001156 28456516 28860494 9619115 27960611 31863866 27320785 29292595 20034800 32067134 32320841 24371229 28403783 30248507 18723488 28787019 7913408 16230404 22030314 20529690 30883116 14980703 26115782 32829012 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:545734-1 | |
| Safety | NA |