| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-856 | |
| Phytochemical name or plant extracts | Canthin-6-one | |
| PMID | 14575431 | |
| Literature evidence | These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines. | |
| IUPAC name | 1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Eurycoma longifolia | |
| Geographical availability | Borneo, Cambodia, Laos, Malaya, Myanmar, Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Roots | |
| Other cancers | Breast cancer, Prostate Cancer, Lung Cancer, Leukemia, Stomach cancer, Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 8.12 ± 0.6 µg/mL against HCC 1395 | |
| Potency | NA | |
| Cell line/ mice model | HCC 1395, DU 145, Vero E6, A549, MCF-7, HL60 , AZ521, SKBR-3 | |
| Additional information | Demonstrates significant antimicrobial and antiproliferative activities, strong inhibition of the DU 145 cells Canthin-6-one presents an interesting cytotoxic activity against leukemic cells and represents a promising scaffold for the development of molecules for anti-leukemic applications, especially by its anti-leukemic stem cell activity. | |
| PubChem ID | 97176 | |
| Additional PMIDs | 32708115 28425165 14575431 28161479 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:813715-1 | |
| Safety | NA |