| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1511 | |
| Phytochemical name or plant extracts | Stachydrine hydrochloride | |
| PMID | 28469788 | |
| Literature evidence | Our results showed that Stachydrine hydrochloride inhibits cell proliferation and induces primary apoptosis and ROS production in T47D and MCF-7 cells in time- and dose-dependent manner. | |
| IUPAC name | (2S)-1,1-dimethylpyrrolidin-1-ium-2-carboxylic acid;chloride | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Leonurus cardiaca | |
| Geographical availability | Albania, Austria, Baltic States, Belarus, Belgium, Bulgaria, Central European Russia, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Greece, Hungary, Iran, Italy, Krym, Netherlands, North European Russia, Northwest European Russia, Norway, Poland, Romania, South European Russia, Sweden, Switzerland, Transcaucasus, Turkey, Turkey-in-Europe, Ukraine, West Siberia, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Bcl-2, AKT, ERK | |
| Gene or Protein evidence | Mechanistically, Stachydrine hydrochloride treatment induced caspase-3 activation and decreased the expression of the anti-apoptotic protein Bcl-2. Moreimportantly, Stachydrine hydrochloride simultaneously inhibited the phosphorylation of Akt and ERK proteins. | |
| Target pathways | Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways | |
| IC50 | IC50 of Stachydrine hydrochloride for MCF-7 and T47D is about 500 µM | |
| Potency | Overall, our data indicated that Stachydrine hydrochloride induces apoptosis in MCF-7 and T47D cells and exerts inhibitory effects on proliferation by concurrently suppressing Akt and ERK survival signals, suggesting its potential efficiency in treatment of breast cancer. | |
| Cell line/ mice model | MCF-7 , T47D | |
| Additional information | Conclusively, our data demonstrated that Stachydrine hydrochloride significantly inhibited growth and induced apoptosis of MCF-7 and T47D breast cancer cells via activating intrinsic cell death signaling and suppressing cell survival signals, suggesting its potential therapeutic value in the prevention or treatment of breast cancer. | |
| PubChem ID | 44150282 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:449168-1 | |
| Safety | NA |