| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-173 | |
| Phytochemical name or plant extracts | Homoharringtonine | |
| PMID | 29788973 | |
| Literature evidence | Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism. | |
| IUPAC name | 1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Cephalotaxus harringtonia | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Hainan, Japan, Korea, Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer, Melanoma | |
| Target gene or protein | Bcl-x, Caspase 9 | |
| Gene or Protein evidence | Homoharringtonine regulates the alternative splicing of Bcl-x and Caspase 9 through a PP1-dependent mechanism. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our study reveals a novel mechanism underlying the antitumor activities of HHT. | |
| Cell line/ mice model | MCF-7, A549, UACC903 | |
| Additional information | In addition, overexpression of PP1 could induce apoptosis and sensitize MCF7 cells to apoptosis induced by HHT. | |
| PubChem ID | 285033 | |
| Additional PMIDs | 12616342 33867824 29788973 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:261818-1 | |
| Safety | NA |