| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1143 | |
| Phytochemical name or plant extracts | Isoliensinine | |
| PMID | 26219228 | |
| Literature evidence | Here, we explored the effects of these alkaloids on triple-negative breast cancer cells and found that among the three alkaloids isoliensinine possesses the most potent cytotoxic effect, primarily by inducing apoptosis. | |
| IUPAC name | (1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Nelumbo nucifera | |
| Geographical availability | Amur, Assam, Bangladesh, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, India, Iran, Japan, Jawa, Khabarovsk, Korea, Laos, Lesser Sunda Is., Malaya, Manchuria, Myanmar, Nepal, New Guinea, North Caucasus, Northern Territory, Pakistan, Philippines, Primorye, Queensland, South European Russi, Sri Lanka, Thailand, Transcaucasus, Ukraine, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Seeds embryo | |
| Other cancers | Breast cancer , Cervical cancer | |
| Target gene or protein | p38 MAPK, JNK, CDK2, p21, AKT, GSK3α | |
| Gene or Protein evidence | Furthermore, inhibitors or specific siRNAs of p38 MAPK and JNK could attenuate apoptosis induced by isoliensinine. Isoliensinine was found to induce cell cycle arrest at the G0/G1 phase by upregulating p21 expression and downregulating CDK2 and cyclin E in breast cancer cells. Upstream, isoliensinine significantly downregulated AKT (S473) phosphorylation and GSK3α expression in a dose- and time-dependent manner. | |
| Target pathways | p38 MAPK and JNK signaling pathways AKT/GSK3α pathway | |
| IC50 | For 24h, 48h, 72h: 108.1 μM against MDA-MB-231 22.78 μM against MDA-MB-231 18.34 μM against MDA-MB-231 | |
| Potency | Our findings thus revealed a novel antitumor effect of isoliensinine on breast cancer cells and may have therapeutic implications. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HeLa, A549, PC3, HepG2, Hep3B, H1299 | |
| Additional information | These findings suggest that isoliensinine can induce cervical cancer cell cycle arrest and apoptosis by inhibiting the AKT/GSK3α pathway, which represents a novel strategy for the treatment of cervical cancer. | |
| PubChem ID | 5274591 | |
| Additional PMIDs | 26219228 34820007 23742976 26811496 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:605422-1 | |
| Safety | Interestingly, isoliensinine showed a much lower cytotoxicity against MCF-10A, a normal human breast epithelial cell line. |